Goutam RS , Kumar V , Lee U , Kim J .

2016R1D1A1B02008770, 2018M3C7A1056285, 2021R1A4A1027355, 2021M3H9A1097557 National Research Foundation of Korea

             fibroblast growth factor binding
             fibroblast growth factor production

Figure 1. Evolutionary analysis of FGF proteins in humans, mice, and Xenopus. A circular rooted phylogenetic tree, depicting evolutionary relation between FGF proteins in Homo sapiens (HS), Mus musculus (MM), and Xenopus tropicalis (XT) was determined by using Clustal Omega and visualized by iTOL The evolutionary range among each protein is proportionate to the branch lengths and different subfamilies of FGF proteins are indicated by different color ranges.

Figure 2. Diagrammatic representation of domain structure of FGF protein. Members of FGF family are classified based on their mode of action. N: amino terminus, SP: signal peptide, NLS: nuclear localization signal, HBS: heparin binding site, SP*: uncleaved bipartite signal sequence, C: carboxyl terminus, SR: serine rich motif.

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