XB-ART-715
Methods Enzymol
2006 Jan 01;406:500-11. doi: 10.1016/S0076-6879(06)06038-1.
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Activation of Rho and Rac by Wnt/frizzled signaling.
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Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes by means of several distinct pathways. Wnt/Fz activation of the small GTPases Rho and Rac has emerged as a key mechanism that regulates cell polarity and movements during vertebrate gastrulation. In this chapter, we describe biochemical assays for the detection of Wnt/Fz activation of Rho and Rac in both mammalian cells and Xenopus embryo explants.
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Species referenced: Xenopus
Genes referenced: akt1 rac1 rho rho.2