Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Genes Dev
2001 Jan 15;152:173-87. doi: 10.1101/gad.862801.
Show Gene links
Show Anatomy links
Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.
Sullivan E
,
Santiago C
,
Parker ED
,
Dominski Z
,
Yang X
,
Lanzotti DJ
,
Ingledue TC
,
Marzluff WF
,
Duronio RJ
.
???displayArticle.abstract???
Replication-associated histone genes encode the only metazoan mRNAs that lack polyA tails, ending instead in a conserved 26-nt sequence that forms a stem-loop. Most of the regulation of mammalian histone mRNA is posttranscriptional and mediated by this unique 3' end. Stem-loop-binding protein (SLBP) binds to the histone mRNA 3' end and is thought to participate in all aspects of histone mRNA metabolism, including cell cycle regulation. To examine SLBP function genetically, we have cloned the gene encoding Drosophila SLBP (dSLBP) by a yeast three-hybrid method and have isolated mutations in dSLBP. dSLBP function is required both zygotically and maternally. Strong dSLBP alleles cause zygotic lethality late in development and result in production of stable histone mRNA that accumulates in nonreplicating cells. These histone mRNAs are cytoplasmic and have polyadenylated 3' ends like other polymerase II transcripts. Hypomorphic dSLBP alleles support zygotic development but cause female sterility. Eggs from these females contain dramatically reduced levels of histone mRNA, and mutant embryos are not able to complete the syncytial embryonic cycles. This is in part because of a failure of chromosome condensation at mitosis that blocks normal anaphase. These data demonstrate that dSLBP is required in vivo for 3' end processing of histone pre-mRNA, and that this is an essential function for development. Moreover, dSLBP-dependent processing plays an important role in coupling histone mRNA production with the cell cycle.
???displayArticle.pubmedLink???
11157774
???displayArticle.pmcLink???PMC312608 ???displayArticle.link???Genes Dev ???displayArticle.grants???[+]
Adams,
The genome sequence of Drosophila melanogaster.
2000, Pubmed
Adams,
The genome sequence of Drosophila melanogaster.
2000,
Pubmed
Akhmanova,
Two types of polyadenated mRNAs are synthesized from Drosophila replication-dependent histone genes.
1997,
Pubmed
Anderson,
Changing rates of histone mRNA synthesis and turnover in Drosophila embryos.
1980,
Pubmed
Bowman,
The coding sequences of mouse H2A and H3 histone genes contains a conserved seven nucleotide element that interacts with nuclear factors and is necessary for normal expression.
1995,
Pubmed
Clark-Adams,
Changes in histone gene dosage alter transcription in yeast.
1988,
Pubmed
Cotten,
Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction.
1988,
Pubmed
Currie,
Structure, expression and duplication of genes which encode phosphoglyceromutase of Drosophila melanogaster.
1994,
Pubmed
Dahanukar,
Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila.
1999,
Pubmed
de la Barre,
Core histone N-termini play an essential role in mitotic chromosome condensation.
2000,
Pubmed
,
Xenbase
DeLisle,
Regulation of histone mRNA production and stability in serum-stimulated mouse 3T6 fibroblasts.
1983,
Pubmed
Dominski,
The polyribosomal protein bound to the 3' end of histone mRNA can function in histone pre-mRNA processing.
1995,
Pubmed
Dominski,
Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing.
2001,
Pubmed
,
Xenbase
Dominski,
Formation of the 3' end of histone mRNA.
1999,
Pubmed
Dominski,
Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.
1999,
Pubmed
Duronio,
Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.
1995,
Pubmed
Duronio,
Developmental control of a G1-S transcriptional program in Drosophila.
1994,
Pubmed
Eliassen,
Role for a YY1-binding element in replication-dependent mouse histone gene expression.
1998,
Pubmed
Freeman,
The condensin complex governs chromosome condensation and mitotic transmission of rDNA.
2000,
Pubmed
Fretzin,
A Drosophila melanogaster H3.3 cDNA encodes a histone variant identical with the vertebrate H3.3.
1991,
Pubmed
Gick,
Generation of histone mRNA 3' ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reaction.
1986,
Pubmed
Hanson,
Efficient extraction and partial purification of the polyribosome-associated stem-loop binding protein bound to the 3' end of histone mRNA.
1996,
Pubmed
Harris,
Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps.
1991,
Pubmed
Hassan,
Daughterless is required for the expression of cell cycle genes in peripheral nervous system precursors of Drosophila embryos.
1997,
Pubmed
Heintz,
The regulation of histone gene expression during the cell cycle.
1991,
Pubmed
Heintz,
Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.
1983,
Pubmed
Henikoff,
Heterochromatic deposition of centromeric histone H3-like proteins.
2000,
Pubmed
Hurt,
A common transcriptional activator is located in the coding region of two replication-dependent mouse histone genes.
1991,
Pubmed
Jakoi,
Molecular cloning of the cDNA for ligatin.
1989,
Pubmed
LaBella,
Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.
1988,
Pubmed
Levine,
Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3' end of the mRNA.
1987,
Pubmed
Lüscher,
RNA 3' processing regulates histone mRNA levels in a mammalian cell cycle mutant. A processing factor becomes limiting in G1-arrested cells.
1987,
Pubmed
Ma,
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
2000,
Pubmed
Martin,
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.
1997,
Pubmed
Marzluff,
Histone 3' ends: essential and regulatory functions.
1992,
Pubmed
Meeks-Wagner,
Normal stoichiometry of histone dimer sets is necessary for high fidelity of mitotic chromosome transmission.
1986,
Pubmed
Melin,
Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors.
1992,
Pubmed
Mowry,
Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's.
1987,
Pubmed
Osley,
The regulation of histone synthesis in the cell cycle.
1991,
Pubmed
Pandey,
Point mutations in the stem-loop at the 3' end of mouse histone mRNA reduce expression by reducing the efficiency of 3' end formation.
1994,
Pubmed
Pandey,
The stem-loop structure at the 3' end of histone mRNA is necessary and sufficient for regulation of histone mRNA stability.
1987,
Pubmed
Richardson,
A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis.
1993,
Pubmed
Rio,
Accurate and efficient pre-mRNA splicing in Drosophila cell-free extracts.
1988,
Pubmed
Robinson,
Nitrocellulose-bound antigen repeatedly used for the affinity purification of specific polyclonal antibodies for screening DNA expression libraries.
1988,
Pubmed
Ross,
Properties of the exonuclease activity that degrades H4 histone mRNA.
1987,
Pubmed
Ross,
Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus.
1986,
Pubmed
Saka,
Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.
1994,
Pubmed
Sauer,
Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.
1995,
Pubmed
Schümperli,
Cell-cycle regulation of histone gene expression.
1986,
Pubmed
Soldati,
Structural and functional characterization of mouse U7 small nuclear RNA active in 3' processing of histone pre-mRNA.
1988,
Pubmed
Stauber,
A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment.
1986,
Pubmed
Stauber,
3' processing of pre-mRNA plays a major role in proliferation-dependent regulation of histone gene expression.
1988,
Pubmed
Strunnikov,
SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.
1995,
Pubmed
Sutani,
Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.
1999,
Pubmed
,
Xenbase
van Daal,
A histone variant, H2AvD, is essential in Drosophila melanogaster.
1992,
Pubmed
Vasserot,
Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor.
1989,
Pubmed
Wang,
The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing.
1996,
Pubmed
Wang,
Two Xenopus proteins that bind the 3' end of histone mRNA: implications for translational control of histone synthesis during oogenesis.
1999,
Pubmed
,
Xenbase
Wang,
Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.
1996,
Pubmed
Wei,
Phosphorylation of histone H3 is required for proper chromosome condensation and segregation.
1999,
Pubmed
Wells,
Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.
1985,
Pubmed
Whitfield,
Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms.
2000,
Pubmed
Woodland,
The synthesis and storage of histones during the oogenesis of Xenopus laevis.
1977,
Pubmed
,
Xenbase
Zhao,
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
2000,
Pubmed
