Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Modulates cadherin-dependent cell-cell adhesion and ce...[+]

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Modulates cadherin-dependent cell-cell adhesion and cell sorting (PubMed:20027292, PubMed:19492039). Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing ntn1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with unc-5 family members. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in signaling cascades downstream of fgfr1, and possibly also other fgfr family members (PubMed:14688794). Plays a role in embryonic morphogenesis, but not in embryonic patterning (PubMed:19492039). [-]

             hypogonadotropic hypogonadism 21 with or without anosmia
             Kallmann syndrome

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD