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Summary Expression Phenotypes Gene Literature (559) GO Terms (11) Nucleotides (309) Proteins (58) Interactants (2233) Wiki
XB-GENEPAGE-485219
???displayGene.symbol???:
 otx2

???displayGene.name???: 
orthodenticle homeobox 2

???displayGene.synonyms???
otx-2 , otx2-a , otx2-b , otxA , Xotx-2 , Xotx2 [+] ( Nomenclature history )

???displayGene.geneFunction???
homeodomain transcription factor

Protein Function :
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer ...[+]



???displayGene.geneInteractants???
Human Physical (38), Co-citation (2195)

Diseases: 


Disease Ontology:
syndromic microphthalmia 5 [+]

MIM:
PITUITARY HORMONE DEFICIENCY, COMBINED, 6; CPHD6 [+]

External Links:
GEO Series :
GSE145619.
1/6
 
Gene ID & Location
Xenbase Gene ID XB-GENE-485220 XB-GENE-485224 XB-GENE-6254039
Gene Symbol otx2 otx2.L otx2.S
Chromosome Chr8 Chr8L Chr8S
???displayGene.molecues??? X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 10.1 Version 10.1
CDS CDS Gene Model CDS Gene Model CDS Gene Model
Entrez Gene 548931 432013 399342
Ensembl Gene otx2 (ENSXETG00000015687)
mRNA RefSeq NCBI Nt  More.. RefSeq RefSeq  More.. RefSeq NCBI Nt  More..
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Reference Proteome Q28FN6 Q6DKN2 Q91813
AlphaFold View on AlphaFold View on AlphaFold View on AlphaFold
???displayGene.genomic??? X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in interactive Genome Browser)
Genomic Synteny Xenbase Simple Synteny Genomicus PANTHER
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: otx2.L
???displayGene.mophenotype???
???displayGene.mosmith??? tgas114a06      
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
???displayGene.human???
HGNC, Alliance, Monarch, MIM, GeneCards OTX2 MIM Ensembl, Protein Atlas, Allen Brain Atlas
???displayGene.mouse???
MGI, Alliance Otx2 MGI, IMPC Ensembl, Allen Brain Atlas, MGI
rat
RGD, Alliance Otx2 Ensembl
???displayGene.zebrafish???
ZFIN, Alliance ZFIN, Alliance otx2a otx2b  ZFIN Ensembl
chicken
GEISHA OTX2 Ensembl
fruit fly
Publications
First Neural induction by the secreted polypeptide noggin., Science 1993  
Most Recent Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development., Nat Commun 2024  
All ???displayGene.papersAll??? 138 ???displayGene.morpholinoPapers??? 18 ???displayGene.omimPapers??? 40 ???displayGene.disOntPapers???
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 8 terms 3 terms 11 terms
KEGG Pathways
KOG [K] Homeobox transcription factor
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks otx2 otx2.L otx2.S
Guide RNAs otx2 gRNA1 otx2 gRNA1
Mutants Xtr.otx2emHorb
Antibodies Otx2 Ab1, Otx2 Ab2, Otx2 Ab3, Otx2 Ab4 Otx2 Ab1, Otx2 Ab2, Otx2 Ab3, Otx2 Ab4, Otx2 Ab5 Otx2 Ab1, Otx2 Ab2, Otx2 Ab3, Otx2 Ab4, Otx2 Ab5
Morpholinos otx2 MO1, otx2 MO2, otx2 MO3 otx2 MO1, otx2 MO2, otx2 MO3 otx2 MO1, otx2 MO2, otx2 MO3
ORFs otx2 ORF1 otx2.L ORF1 otx2.S ORF1
Clones EXRC, Horizon Horizon Horizon
Plasmids Addgene.org Addgene.org


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