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XB-GENEPAGE-485219
???displayGene.symbol???: otx2
???displayGene.name???: orthodenticle homeobox 2
???displayGene.synonyms???
otx-2
,
otx2-a
,
otx2-b
,
otxA
,
Xotx-2
,
Xotx2
[+]
(
???displayGene.geneFunction??? homeodomain transcription factor Protein Function :
May play a central role in the initial events of axis formation and in particular in specifying anterior head regions and their spatial relationship with trunk structures. Activates the head organizer ...[+]
???displayGene.geneInteractants???
Human Physical (38), Co-citation (2195)
Diseases: Disease Ontology: syndromic microphthalmia 5
MIM:
PITUITARY HORMONE DEFICIENCY, COMBINED, 6; CPHD6
External Links:
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Gene ID & Location |
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Xenbase Gene ID | XB-GENE-485220 | XB-GENE-485224 | XB-GENE-6254039 | |||||||||
Gene Symbol | otx2 | otx2.L | otx2.S | |||||||||
Chromosome | Chr8 | Chr8L | Chr8S | |||||||||
???displayGene.molecues??? | X. tropicalis | X. laevis.L | X. laevis.S | |||||||||
Genomic Sequence | Version 10.0 | Version 10.1 | Version 10.1 | |||||||||
CDS | CDS Gene Model | CDS Gene Model | CDS Gene Model | |||||||||
Entrez Gene | 548931 | 432013 | 399342 | |||||||||
Ensembl Gene | otx2 (ENSXETG00000015687) | |||||||||||
mRNA |
RefSeq
NCBI Nt
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RefSeq
RefSeq
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RefSeq
NCBI Nt
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Protein |
RefSeq
Swiss-Prot
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RefSeq
Swiss-Prot
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RefSeq
Swiss-Prot
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Reference Proteome | Q28FN6 | Q6DKN2 | Q91813 | |||||||||
AlphaFold | View on AlphaFold | View on AlphaFold | View on AlphaFold | |||||||||
???displayGene.genomic??? | X. tropicalis | X. laevis.L | X. laevis.S | |||||||||
Genome Browser (Click image to open in interactive Genome Browser) |
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Genomic Synteny | Xenbase Simple Synteny Genomicus PANTHER | |||||||||||
???displayGene.expression??? | Development Stages Embryonic Tissues Adult Tissues | |||||||||||
Summary for
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More Information |
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Proteomics | X. tropicalis | X. laevis.L | X. laevis.S | |||||||||
Embryonic Protein Expression | Stage profile: otx2.L | |||||||||||
???displayGene.mophenotype??? | ||||||||||||
???displayGene.mosmith??? | tgas114a06 | |||||||||||
Orthology |
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???displayGene.human??? |
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???displayGene.mouse??? |
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rat |
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???displayGene.zebrafish??? |
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chicken |
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fruit fly |
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Publications | ||||||||||||
First |
Neural induction by the secreted polypeptide noggin., Science 1993 |
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Most Recent |
Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development., Nat Commun 2024 |
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All | ???displayGene.papersAll??? 138 ???displayGene.morpholinoPapers??? 18 ???displayGene.omimPapers??? 40 ???displayGene.disOntPapers??? | |||||||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||||||
GO | 8 terms | 3 terms | 11 terms | |||||||||
KEGG Pathways | ||||||||||||
KOG |
[K] Homeobox transcription factor
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||||||
CRISPRscan Tracks | otx2 | otx2.L | otx2.S | |||||||||
Guide RNAs | otx2 gRNA1 | otx2 gRNA1 | ||||||||||
Mutants | Xtr.otx2emHorb | |||||||||||
Antibodies | Otx2 Ab1, Otx2 Ab2, Otx2 Ab3, Otx2 Ab4 | Otx2 Ab1, Otx2 Ab2, Otx2 Ab3, Otx2 Ab4, Otx2 Ab5 | Otx2 Ab1, Otx2 Ab2, Otx2 Ab3, Otx2 Ab4, Otx2 Ab5 | |||||||||
Morpholinos | otx2 MO1, otx2 MO2, otx2 MO3 | otx2 MO1, otx2 MO2, otx2 MO3 | otx2 MO1, otx2 MO2, otx2 MO3 | |||||||||
ORFs | otx2 ORF1 | otx2.L ORF1 | otx2.S ORF1 | |||||||||
Clones | EXRC, Horizon | Horizon | Horizon | |||||||||
Plasmids | Addgene.org | Addgene.org |
Symbol legend: Blast sequence View sequence Literature or expression images Hover cursor for info