Cdk7 is a cyclin-dependent kinase acting as the catalytic subunit of the cdk-activating kinase complex and the general transcription factor tfiih. It phosphorylates the carboxy-terminal domain of RNA p...[+]

Cdk7 is a cyclin-dependent kinase acting as the catalytic subunit of the cdk-activating kinase complex and the general transcription factor tfiih. It phosphorylates the carboxy-terminal domain of RNA polymerase II to regulate transcription initiation and other cdks to control cell cycle progression. The protein localizes to the nucleus. Expression is found in the developing eye, brain, spinal cord, and somites during embryogenesis. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD