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Summary Expression Phenotypes Gene Literature (42) GO Terms (11) Nucleotides (105) Proteins (50) Interactants (564) Wiki
XB-GENEPAGE-920721
???displayGene.symbol???:
 lmna

???displayGene.name???: 
lamin A/C

???displayGene.synonyms???
lamin a , Lamin-A , LOC108700617 ( Nomenclature history )

???displayGene.geneFunction???
nucleoskeletal protein

Protein Function :
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also inter...[+]



???displayGene.geneInteractants???
Human Physical (302), Co-citation (262)

Diseases: 


Disease Ontology:
autosomal dominant Emery-Dreifuss muscular dystrophy 2 [+]

MIM:
HEART-HAND SYNDROME, SLOVENIAN TYPE [+]

External Links:
 
Gene ID & Location
Xenbase Gene ID XB-GENE-920722 XB-GENE-920728 XB-GENE-17342018
Gene Symbol lmna lmna.L lmna.S
Chromosome Chr8 Chr8L Chr8S
???displayGene.molecues??? X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 10.1 Version 10.1
CDS CDS Gene Model CDS Gene Model CDS Gene Model
Entrez Gene 733973 373673 108700617
Ensembl Gene lmna (ENSXETG00000024161)
mRNA RefSeq NCBI Nt  More.. RefSeq NCBI Nt RefSeq
Protein RefSeq  More.. RefSeq Swiss-Prot  More.. RefSeq
Reference Proteome Q28BY8 P11048
AlphaFold View on AlphaFold View on AlphaFold
???displayGene.genomic??? X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in interactive Genome Browser)
Genomic Synteny Xenbase Simple Synteny Genomicus PANTHER
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: lmna.L Stage profile: lmna.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
???displayGene.human???
HGNC, Alliance, Monarch, MIM, GeneCards LMNA MIM Ensembl, Protein Atlas, Allen Brain Atlas
???displayGene.mouse???
MGI, Alliance Lmna MGI, IMPC Ensembl, Allen Brain Atlas, MGI
rat
RGD, Alliance Lmna Ensembl
???displayGene.zebrafish???
ZFIN, Alliance lmna  ZFIN Ensembl
chicken
GEISHA LMNAL Ensembl
fruit fly
Publications
First Differential expression of nuclear lamin proteins during chicken development., J Cell Biol 1987  
Most Recent Amphibian mast cells serve as barriers to chytrid fungus infections., Elife 2024     
All ???displayGene.papersAll??? 2 ???displayGene.morpholinoPapers??? 3 ???displayGene.omimPapers??? 4 ???displayGene.disOntPapers???
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 5 terms 11 terms 0 terms
KEGG Pathways Apoptosis Apoptosis
KOG [DY] Nuclear envelope protein lamin, intermediate filament superfamily
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks lmna.L
Guide RNAs lmna gRNA1 lmna gRNA1
Mutants Xtr.lmnaemHorb
Antibodies Lmna Ab1, Lmna Ab2, Lmnb2/3 Ab5 Lmna Ab1, Lmna Ab2, Lmnb2/3 Ab5 Lmna Ab2, Lmnb2/3 Ab5
Clones Horizon Horizon Horizon
Plasmids Addgene.org Addgene.org


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info