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Summary Expression Phenotypes Gene Literature (31) GO Terms (6) Nucleotides (124) Proteins (52) Interactants (343) Wiki
XB-GENEPAGE-494739
???displayGene.symbol???:
 mecp2

???displayGene.name???: 
methyl-CpG binding protein 2

???displayGene.synonyms???
( Nomenclature history )

???displayGene.geneFunction???
methyl-CpG binding transcription factor

Protein Function :
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and...[+]


InterPro :
Methyl CpG DNA-bd, Me CpG-bd MeCP2, DNA-bd dom sf, MeCP2/MBD4

???displayGene.geneInteractants???
Human Physical (144), Co-citation (199)

Diseases: 


Disease Ontology:
severe congenital encephalopathy due to MECP2 mutation [+]

MIM:
INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, LUBS TYPE; MRXSL [+]

External Links:
1/5
 
Gene ID & Location
Xenbase Gene ID XB-GENE-494740 XB-GENE-17346751 XB-GENE-494744
Gene Symbol mecp2 mecp2.L mecp2.S
Chromosome Chr8 Chr8L Chr8S
???displayGene.molecues??? X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 10.1 Version 10.1
CDS CDS Gene Model CDS Gene Model CDS Gene Model
Entrez Gene 100216110 108704791 398087
Ensembl Gene mecp2 (ENSXETG00000014242)
mRNA RefSeq NCBI Nt  More.. NCBI Nt RefSeq NCBI Nt  More..
Protein RefSeq  More.. NCBI Protein RefSeq  More..
Reference Proteome B4F6Y0 Q9YGC6
AlphaFold View on AlphaFold View on AlphaFold
???displayGene.genomic??? X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in interactive Genome Browser)
Genomic Synteny Xenbase Simple Synteny Genomicus PANTHER
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: mecp2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
???displayGene.human???
HGNC, Alliance, Monarch, MIM, GeneCards MECP2 MIM Ensembl, Protein Atlas, Allen Brain Atlas
???displayGene.mouse???
MGI, Alliance Mecp2 MGI, IMPC Ensembl, Allen Brain Atlas, MGI
rat
RGD, Alliance Mecp2 Ensembl
???displayGene.zebrafish???
ZFIN, Alliance mecp2  ZFIN Ensembl
chicken
GEISHA OTUD5 Ensembl
fruit fly
Publications
First Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription., Nat Genet 1998  
Most Recent A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation., Nat Commun 2023     
All ???displayGene.papersAll??? 3 ???displayGene.morpholinoPapers??? 3 ???displayGene.omimPapers??? 4 ???displayGene.disOntPapers???
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 3 terms 0 terms 6 terms
KEGG Pathways
KOG [KB] Methyl-CpG binding transcription regulators
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mecp2 mecp2.L mecp2.S
Antibodies Mecp2 Ab1 Mecp2 Ab1
Morpholinos mecp2 MO2 mecp2 MO2 mecp2 MO2
ORFs mecp2 ORF1
Clones Horizon Horizon Horizon
Plasmids Addgene.org Addgene.org


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