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Summary Expression Phenotypes Gene Literature (162) GO Terms (10) Nucleotides (553) Proteins (65) Interactants (399) Wiki
XB-GENEPAGE-5810263
???displayGene.symbol???:
 tpx2

???displayGene.name???: 
TPX2, microtubule-associated

???displayGene.synonyms???
dil-2 , dil2 , hctp4 , repp86 , tpx2-a , tpx2-b [+] ( Nomenclature history )

???displayGene.geneFunction???
Immunoglobin and related proteins

Protein Function :
Spindle assembly factor. Required for normal assembly of mitotic spindles. Mediates the binding kif15 and aurka to spindle microtubules. Required for targeting kif15 to microtubule minus ends. Activate...[+]



???displayGene.geneInteractants???
Human Physical (24), Co-citation (375)

Diseases: 


Disease Ontology:
prostate cancer

MIM:
PROSTATE CANCER

External Links:
1/3
 
Gene ID & Location
Xenbase Gene ID XB-GENE-5810264 XB-GENE-6251919 XB-GENE-6255926
Gene Symbol tpx2 tpx2.L tpx2.S
Chromosome Chr10 Chr9_10L Chr9_10S
???displayGene.molecues??? X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 10.1 Version 10.1
CDS CDS Gene Model CDS Gene Model CDS Gene Model
Entrez Gene 100124787 398174 446586
Ensembl Gene tpx2 (ENSXETG00000002548)
mRNA RefSeq NCBI Nt  More.. RefSeq NCBI Nt  More.. RefSeq RefSeq  More..
Protein RefSeq Swiss-Prot  More.. RefSeq  More.. RefSeq Swiss-Prot  More..
Reference Proteome A4IH24 A0A8J0TJ15 Q6DDV8
AlphaFold View on AlphaFold View on AlphaFold View on AlphaFold
???displayGene.genomic??? X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in interactive Genome Browser)
Genomic Synteny Xenbase Simple Synteny Genomicus PANTHER
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
???displayGene.human???
HGNC, Alliance, Monarch, MIM, GeneCards TPX2 MIM Ensembl, Protein Atlas, Allen Brain Atlas
???displayGene.mouse???
MGI, Alliance Tpx2 MGI, IMPC Ensembl, Allen Brain Atlas, MGI
rat
RGD, Alliance Tpx2 Ensembl
???displayGene.zebrafish???
ZFIN, Alliance tpx2  ZFIN Ensembl
chicken
GEISHA TPX2 Ensembl
fruit fly
Publications
First Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein., J Cell Biol 1998     
Most Recent Exploring the clinical significance of TPX2 in pancreatic cancer: from biomarker to immunotherapy., Naunyn Schmiedebergs Arch Pharmacol 2024  
All ???displayGene.papersAll??? 2 ???displayGene.morpholinoPapers??? 4 ???displayGene.omimPapers??? 11 ???displayGene.disOntPapers???
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 7 terms 16 terms 8 terms
KEGG Pathways
KOG [RP] FOG: Immunoglobin and related proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks tpx2.L tpx2.S
Morpholinos tpx2 MO1
ORFs tpx2 ORF1 tpx2.S ORF1
Clones Horizon Horizon Horizon
Plasmids Addgene.org Addgene.org


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