Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (401) GO Terms (14) Nucleotides (229) Proteins (58) Interactants (1856) Wiki
XB-GENEPAGE-479317
???displayGene.symbol???:
 notch1

???displayGene.name???: 
notch 1 receptor

???displayGene.synonyms???
notch , notch-1 , xnotch , x-notch-1 , xnotch1 , xotch [+] ( Nomenclature history )

???displayGene.geneFunction???
signal transduction, receptor for delta class ligands

Protein Function :
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellul...[+]



???displayGene.geneInteractants???
Human Physical (16), Co-citation (1840)

Diseases: 


Disease Ontology:
aortic valve stenosis [+]

MIM:
ADAMS-OLIVER SYNDROME 5; AOS5 [+]

External Links:
GEO Series :
GSE76342.
1/5
 
Gene ID & Location
Xenbase Gene ID XB-GENE-479318 XB-GENE-17342057 XB-GENE-865261
Gene Symbol notch1 notch1.L notch1.S
Chromosome Chr8 Chr8L Chr8S
???displayGene.molecues??? X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 10.1 Version 10.1
CDS CDS Gene Model CDS Gene Model CDS Gene Model
Entrez Gene 100037842 108698191 394367
Ensembl Gene notch1 (ENSXETG00000000757)
mRNA RefSeq NCBI Nt  More.. NCBI Nt RefSeq NCBI Nt
Protein RefSeq Swiss-Prot  More.. NCBI Protein TrEMBL  More.. RefSeq Swiss-Prot  More..
Reference Proteome A2RUV0 A0A1L8F627 P21783
AlphaFold View on AlphaFold View on AlphaFold View on AlphaFold
???displayGene.genomic??? X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in interactive Genome Browser)
Genomic Synteny Xenbase Simple Synteny Genomicus PANTHER
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: notch1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
???displayGene.human???
HGNC, Alliance, Monarch, MIM, GeneCards NOTCH1 MIM Ensembl, Protein Atlas, Allen Brain Atlas
???displayGene.mouse???
MGI, Alliance Notch1 MGI, IMPC Ensembl, Allen Brain Atlas, MGI
rat
RGD, Alliance Notch1 Ensembl
???displayGene.zebrafish???
ZFIN, Alliance ZFIN, Alliance notch1b notch1a  ZFIN Ensembl
chicken
GEISHA NOTCH1 Ensembl
fruit fly
Publications
First Cell patterning in pigment-chimeric eyes in Xenopus: germinal transplants and their contributions to growth of the pigmented retinal epithelium., Proc Natl Acad Sci U S A 1987     
Most Recent Nodal and churchill1 position the expression of a notch ligand during Xenopus germ layer segregation., Life Sci Alliance null  
All ???displayGene.papersAll??? 54 ???displayGene.morpholinoPapers??? 6 ???displayGene.omimPapers??? 19 ???displayGene.disOntPapers???
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 10 terms 9 terms 11 terms
KEGG Pathways Notch signaling pathway Notch signaling pathway Notch signaling pathway
KOG [O] 26S proteasome regulatory complex, subunit PSMD10
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks notch1 notch1.L notch1.S
Guide RNAs notch1 gRNA1 notch1 gRNA1 notch1 gRNA1
Antibodies Notch1 AB1 Notch1 AB1 Notch1 AB1
Morpholinos notch1 MO1 notch1 MO1
Clones Horizon Horizon EXRC, Horizon
Plasmids Addgene.org Addgene.org


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info