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Summary Expression Phenotypes Gene Literature (19) GO Terms (25) Nucleotides (65) Proteins (39) Interactants (201) Wiki
XB-GENEPAGE-483794
???displayGene.symbol???:
 gdnf

???displayGene.name???: 
glial cell derived neurotrophic factor

???displayGene.synonyms???
gdnf-a , gdnf-b , hfb1-gdnf ( Nomenclature history )

???displayGene.geneFunction???
TGF-beta related peptide growth factor

Protein Function :
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.



???displayGene.geneInteractants???
Human Physical (10), Co-citation (191)

Diseases: 


Disease Ontology:
congenital central hypoventilation syndrome [+]

MIM:
HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 3; HSCR3 [+]

External Links:
1/6
 
Gene ID & Location
Xenbase Gene ID XB-GENE-483795 XB-GENE-865016 XB-GENE-6464346
Gene Symbol gdnf gdnf.L gdnf.S
Chromosome Chr1 Chr1L Chr1S
???displayGene.molecues??? X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 10.1 Version 10.1
CDS CDS Gene Model CDS Gene Model CDS Gene Model
Entrez Gene 100498061 779087 100337571
Ensembl Gene gdnf (ENSXETG00000004782)
mRNA NCBI Nt RefSeq NCBI Nt  More.. RefSeq NCBI Nt
Protein NCBI Protein RefSeq Swiss-Prot  More.. RefSeq  More..
Reference Proteome F6UI64 Q06PM8 C7S813
AlphaFold View on AlphaFold View on AlphaFold View on AlphaFold
???displayGene.genomic??? X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in interactive Genome Browser)
Genomic Synteny Xenbase Simple Synteny Genomicus PANTHER
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
???displayGene.human???
HGNC, Alliance, Monarch, MIM, GeneCards GDNF MIM Ensembl, Protein Atlas, Allen Brain Atlas
???displayGene.mouse???
MGI, Alliance Gdnf MGI, IMPC Ensembl, Allen Brain Atlas, MGI
rat
RGD, Alliance Gdnf Ensembl
???displayGene.zebrafish???
ZFIN, Alliance ZFIN, Alliance gdnfb gdnfa  ZFIN Ensembl
chicken
GEISHA GDNF Ensembl
fruit fly
Publications
First GDNF signalling through the Ret receptor tyrosine kinase., Nature 1996  
Most Recent Isthmin-1: A critical regulator of branching morphogenesis and metanephric mesenchyme condensation during early kidney development., Bioessays 2024  
All ???displayGene.papersAll??? 1 ???displayGene.omimPapers??? 1 ???displayGene.disOntPapers???
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 8 terms 22 terms 7 terms
KEGG Pathways Calcium signaling pathway Calcium signaling pathway Calcium signaling pathway
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks gdnf gdnf.L gdnf.S
ORFs gdnf ORF1
Clones Horizon Horizon Horizon
Plasmids Addgene.org Addgene.org


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info