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Summary Expression Phenotypes Gene Literature (9) GO Terms (5) Nucleotides (98) Proteins (48) Interactants (64) Wiki
XB-GENEPAGE-988967
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 apaf1

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apoptotic peptidase activating factor 1

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apaf-1 ( Nomenclature history )

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apoptosis/apoptosome scaffold protein with WD-40 domains, caspase recruitment domain (CARD), and an ATPase domain

Protein Function :
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.


InterPro :
Tc1-like DDE dom, WH-like DNA-bd sf, Transposase Tc1-like, Homeobox-like sf, [+]

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Diseases: 


External Links:
 
???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info