The lin28b gene encodes an rna-binding protein localized to the cytoplasm. It functions in primordial germ cell migration and survival, and regulates the timing of developmental events by binding to an...[+]

The lin28b gene encodes an rna-binding protein localized to the cytoplasm. It functions in primordial germ cell migration and survival, and regulates the timing of developmental events by binding to and blocking the processing of specific micrornas, including the let-7 family. Expression is detected in the germ plasm, migrating primordial germ cells, brain, spinal cord, eye, branchial arches, and pronephros during embryogenesis. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD