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XB-PHENO-21732

Xla Wt + Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A + mycn, Wylie LA et al. (2015)

Experiment + Assay: Xla Wt + Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A + mycn + NF18-19 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A) ascl1.S
ascl1.L
 NF stage 2 (2-cell) blastomere
mRNA injection mycn.S mycn.L
mycn.S
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 18 to NF stage 19  
Expression Phenotypes (2):
decreased amount hand2.L expression in anterior placodal area
decreased amount th.S expression in anterior placodal area
Source: Fig.7.a,b
Article: XB-ART-50246, PubMed