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XB-PHENO-22974

Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX, Rankin SA et al. (2015)

Experiment + Assay: Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX + NF35/36 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Mmu.lef1-Mmu.ctnnb1-GR) ctnnb1.L
ctnnb1.S
 NF stage 4 (8-cell) blastomere
chemical dexamethasone
NF stage 28 whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36  
Anatomical Phenotypes: abnormal development of lung , abnormally localised lung bud , abnormal Wnt signaling pathway , increased size of the lung bud
Expression Phenotypes (2):
mislocalised nkx2-1.L expression in lung bud
increased amount nkx2-1.L expression in lung bud
Source: fig.10.r
Article: XB-ART-49397, PubMed