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XB-PHENO-22976

Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + wnt2 MO + DEX, Rankin SA et al. (2015)

Experiment + Assay: Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + wnt2 MO + DEX + NF35/36 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection wnt2 MO1 wnt2.S
wnt2.L
 NF stage 3 (4-cell) blastomere
mRNA injection Tg(Mmu.lef1-Mmu.ctnnb1-GR) ctnnb1.L
ctnnb1.S
 NF stage 4 (8-cell) blastomere
chemical dexamethasone
NF stage 28 whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36  
Anatomical Phenotypes: abnormal development of lung
Expression Phenotypes (3):
mislocalised lung bud that expresses nkx2-1.L
increased amount lung bud that expresses nkx2-1.L
increased amount nkx2-1.L expression in lung bud
Source: fig.10.t
Article: XB-ART-49397, PubMed