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XB-PHENO-22978

Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX + PD173074, Rankin SA et al. (2015)

Experiment + Assay: Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX + PD173074 + NF35/36 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Mmu.lef1-Mmu.ctnnb1-GR) ctnnb1.L
ctnnb1.S
 NF stage 4 (8-cell) blastomere
chemical 219580-11-7
NF stage 25 whole organism
chemical dexamethasone
NF stage 28 whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36  
Anatomical Phenotypes: abnormal development of lung
Expression Phenotypes (4):
mislocalised lung bud that expresses nkx2-1.L
increased amount lung bud that expresses nkx2-1.L
mislocalised nkx2-1.L expression in lung bud
increased amount nkx2-1.L expression in lung bud
Source: fig.10.v
Article: XB-ART-49397, PubMed