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XB-PHENO-23019

Xtr Wt + Mmu.osr1-GR + osr1 MO + osr2 MO, Rankin SA et al. (2012)

Experiment + Assay: Xtr Wt + Mmu.osr1-GR + osr1 MO + osr2 MO + NF35/36 (in situ hybridization)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection osr1 MO1 osr1
 NF stage 4 (8-cell) blastomere
morpholino injection osr2 MO1 osr2
 NF stage 4 (8-cell) blastomere
mRNA injection Tg(Mmu.osr1-GR) osr1
 NF stage 4 (8-cell) blastomere D2
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36  
Anatomical Phenotypes: abnormal development of foregut , abnormal development of lung
Expression Phenotypes (2):
decreased amount nkx2-1 expression in foregut epithelium
decreased amount sox2 expression in foregut epithelium
Source: fig.2.e,e^1
Article: XB-ART-45616, PubMed