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XB-PHENO-23535

Xla Wt + adprhl1 MO, Smith SJ et al. (2020)

Experiment + Assay: Xla Wt + adprhl1 MO + NF41 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection adprhl1 MO1 adprhl1 (Xla)
 NF stage 3 (4-cell) left-dorsal blastomere
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 41 Myh6 Ab1
immunohistochemistry NF stage 41 Adprhl1 Ab1
Anatomical Phenotypes: abnormal actin cytoskeleton morphology , abnormal development of cardiac ventricle , abnormal myofibril morphology
Expression Phenotypes (2):
decreased amount myh6.L expression in cardiac myocyte
decreased amount myh6.L expression in cardiac ventricle
Source: Fig.S2.2B-2E
Article: XB-ART-57216, PubMed