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XB-PHENO-23892

Xla Wt + six1, Shah AM et al. (2020)

Experiment + Assay: Xla Wt + six1 + NF16-18 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection six1 (Xla) six1 (Xla)
 NF stage 4 (8-cell) animal blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 16 to NF stage 18  
Expression Phenotypes (2):
decreased amount zic2.L expression in neural crest
increased amount zic2.L expression in pre-chordal neural plate
Human Disease Associations: branchiootic syndrome, branchiootorenal syndrome
Source: Fig. 2 K
Article: XB-ART-56645, PubMed