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XB-PHENO-23895

Xla Wt + Six1-Y129C, Shah AM et al. (2020)

Experiment + Assay: Xla Wt + Six1-Y129C + NF16-18 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(six1-Y129C) six1 (Xla)
 NF stage 4 (8-cell) animal blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 16 to NF stage 18  
Expression Phenotypes (2):
increased amount sox9.L expression in neural crest
increased amount sox9.L expression in otic placode
Human Disease Associations: branchiootic syndrome, branchiootorenal syndrome
Source: Fig. 2 O
Article: XB-ART-56645, PubMed