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XB-PHENO-23907

Xla Wt + six1-W122R, Shah AM et al. (2020)

Experiment + Assay: Xla Wt + six1-W122R + NF28-32 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(six1-W122R) six1 (Xla)
 NF stage 8 animal blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28 to NF stage 32  
Expression Phenotypes (2):
increased amount sox9.L expression in otic vesicle
decreased amount sox9.L expression in otic vesicle
Human Disease Associations: branchiootic syndrome, branchiootorenal syndrome
Source: Fig. 4 A, Fig. 5 D
Article: XB-ART-56645, PubMed