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XB-PHENO-24131

Xtr Wt + zmym2 MO, Connaughton DM et al. (2020)

Experiment + Assay: Xtr Wt + zmym2 MO + NF28 (in situ hybridization)
Background: Xtr.Nigerian AKhok
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection zmym2 MO1 zmym2
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28  
Anatomical Phenotypes: abnormal pronephric kidney morphology , decreased size of the duct , decreased size of the pronephric kidney
Expression Phenotypes (1):
decreased amount atp1a1 expression in pronephric duct
Human Disease Associations: CAKUT
Source: Fig. 2 B C D E
Article: XB-ART-57582, PubMed