Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-PHENO-24246

Xla Wt + ptpn11N308D, Langdon Y et al. (2012)

Experiment + Assay: Xla Wt + ptpn11N308D + NF37/38 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
DNA injection Tg(ptpn11N308D) ptpn11 (Xla)
 NF stage 1 embryo
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 37 and 38 Tpm1 Ab1
Anatomical Phenotypes: abnormal heart morphology , abnormally decreased number of sarcomere , increased size of the extracellular matrix
Expression Phenotypes (2):
increased amount actc1.L expression in myocardium
increased amount fbn1.L expression in myocardium
Human Disease Associations: Noonan syndrome
Source: Fig. 5 CFI
Article: XB-ART-44762, PubMed