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XB-PHENO-24263

Xtr Wt + fgfr4 CRISPR, Sempou E et al. (2018)

Experiment + Assay: Xtr Wt + fgfr4 CRISPR + NF17 (immunohistochemistry)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR fgfr4 fgfr4
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 17 to NF stage 17 myod1 Ab2
Anatomical Phenotypes: abnormal gastrocoel roof plate morphology , abnormal left-right organizer morphology , decreased size of the presomitic mesoderm
Expression Phenotypes (2):
decreased amount myod1 expression in gastrocoel roof plate
decreased amount myod1 expression in left-right organizer
Human Disease Associations: congenital heart disease, visceral heterotaxy
Source: Fig. 3 I-K
Article: XB-ART-55550, PubMed