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XB-PHENO-24644

Xtr Wt + Hsa.NEK2, Endicott SJ et al. (2015)

Experiment + Assay: Xtr Wt + Hsa.NEK2 + NF28 (in situ hybridization)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Hsa.NEK2) nek2
 NF stage 1
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28 to NF stage 28  
Anatomical Phenotypes: abnormal determination of left/right symmetry in lateral plate mesoderm
Expression Phenotypes (2):
absent pitx2 expression in lateral plate mesoderm
mislocalised pitx2 expression in lateral plate mesoderm
Human Disease Associations: visceral heterotaxy
Source: Fig. 1 B
Article: XB-ART-51433, PubMed