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XB-PHENO-24795

Xla Wt + bicc1 MO + dand5 MO, Maerker M et al. (2021)

Experiment + Assay: Xla Wt + bicc1 MO + dand5 MO + NF32 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection bicc1 MO4 bicc1 (Xla)
 NF stage 3 (4-cell) left blastomere
morpholino injection dand5 MO4 dand5 (Xla)
 NF stage 3 (4-cell) left blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 32 to NF stage 32  
Anatomical Phenotypes: abnormal determination of left/right symmetry in lateral plate mesoderm
Expression Phenotypes (1):
absent pitx2.L expression in lateral plate mesoderm
Source: Fig. 5 D, Sup Fig. 5 B
Article: XB-ART-58455, PubMed