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XB-PHENO-25586

Xla Wt + cyp26a1, Gur M et al. (2022)

Experiment + Assay: Xla Wt + cyp26a1 + NF29/30 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection cyp26a1.L cyp26a1.L
 NF stage 3 (4-cell) left-dorsal blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 29 and 30  
Anatomical Phenotypes: absent eye , decreased size of the cement gland , decreased size of the head
Expression Phenotypes (1):
decreased amount muc2.L expression in cement gland
Human Disease Associations: microcephaly
Source: Fig.1.B,D
Article: XB-ART-58916, PubMed