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XB-PHENO-27139

Xla Wt + hwa + dkk1, Azbazdar Y and De Robertis EM (2024)

Experiment + Assay: Xla Wt + hwa + dkk1 + NF28 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection dkk1 (Xla) dkk1 (Xla)
 NF stage 3 (4-cell) whole organism
mRNA injection hwa (Xla) hwa (Xla)
 NF stage 3 (4-cell) whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 28  
Anatomical Phenotypes: abnormal head , absent tail , absent tail bud , wholly anteriorized embryo
Expression Phenotypes (1):
increased amount sox2.L expression in brain
Source: Fig 5 D'G'
Article: XB-ART-60778, PubMed