XB-LINE-1134
Line Name: Xtr.npntinsZimml
| Summary |
|
| Synonym: |
xdm, xenopus de milo, T388, Xtr.Tg(nkx2.5:GFP) |
| Species: |
Xenopus tropicalis |
| Background Strain: |
Xtr.inbred
|
| Description: |
Nephronectin insertional mutation (probably null). Insertion of Tg(nkx2.5:GFP) transgene between 3rd and 4th exon of npnt gene causing mRNA truncation. |
| Phenotype Description: |
Homozygous mutants fail to form forelimb buds and all subsequent forelimb structures. Hindlimb development and all other tissues seem to form normally. Cardiac fluorescence due to GFP.
|
| Color Morph: |
pigmented |
| Breeding Type: |
OUTBRED
|
| Lab of Origin: |
Zimmerman Lab |
| Line Type: |
Mutant, Transgenic |
| Mutated Gene(s): |
npnt
|
| MTA Required: |
No
|
| Public: |
Yes
|
| Anatomical Phenotypes: |
npnt |
|
Xtr.npnt{insZimml} froglets which carry a transgenic insertion (nkx2-5:GFP) in the npnt gene. It was the first insertional mutation to be cloned in Xenopus.
|
|
Homozyogote Xtr.npnt mutant froglets lack forelimbs, as seen in this skeletal preparation.
|
| Stock Center |
RRID |
Generation |
DOB |
# Males |
# Females |
Availability |
Mutant Details |
| EXRC (Europe) |
EXRC_6008 |
|
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