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XB-LINE-997
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Line Name: Xtr.Tg(WntREs:dEGFP;CMV:dsRed)Vlemx
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| Summary | |
|---|---|
| Synonym: | pbin7Lef:dGFP F2, pbin7Lef:dGFP-H (F2) |
| Species: | Xenopus tropicalis |
| Background Strain: | Xtr.Outbred |
| Paternal Line: | |
| Maternal Line: | |
| Description: | The inserted transgene construct contains a synthetic Wnt-responsive promoter consisting of 7 copies of a TCF/LEF1 binding DNA element, a minimal TATA box and a reporter gene encoding destabilized EGFP and a polyA sequence. The transgene is flanked on both sides by two copies of the chicken HS4-core sequence. See Tran et al., 2010 and 2013 for a full description. Likely due to a (unknown) transgene integration event, the animals can produce pseudo-albino (no red eyes) off-spring. |
| Phenotype Description: | GFP expression reveals dynamic patterns of Wnt/beta-catenin signaling activity First clear signals present at neurula stage (NF stage 19) in the neural folds. |
| Color Morph: | albino |
| Breeding Type: | UNKNOWN |
| Lab of Origin: | |
| Line Type: | Transgenic |
| Mutated Gene(s): | |
| MTA Required: | No |
| Public: | Yes |
| Catalogue Number: |
| Stock Center | RRID | Generation | Availability | Mutant Details | Information  |
|---|---|---|---|---|---|
| NXR (US) | |||||
| EXRC (Europe) | |||||
| NBRP (Japan) | |||||
| XLRRI (US) | |||||
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