FIG. 3. Localization of MuSK mRNA by whole-mount in situ hybridization. (AâI) Anti-sense probe, (J) sense probe as control. (AâD) Lateral view: (A) stage 22, (B) stage 25, (C) stage 28, (D) stage 45. MuSK mRNA was localized in the myotomes as well as in the CNS in embryos during different stages of myotomal NMJ formation (AâC). After this period, mRNA expression is down-regulated in the myotomal musculature (D). (EâI) Dorsal view: (E) stage 22, (F) stage 28, (G) stage 40, (H, I) dorsal part of the embryo only. In this view, the expression of the MuSK mRNA in both neural tube (NT) and myotomes (MT) is clearly seen. Within the CNS, the eye vesicle is a prominent site of mRNA expression. No labelling was seen at all stages when the embryos were labelled with the sense probe (J).
Image published in: Fu AK et al. (1999)
Copyright © 1999. Image reproduced with permission of the Publisher, John Wiley & Sons.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| musk.S | LOC108695348 | X. laevis | Sometime during NF stage 22 to NF stage 45 | neural tube posterior neural tube anterior neural tube central nervous system brain spinal cord eye somite myotome presomitic mesoderm tail bud optic vesicle |
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