Fig. S1. Endogenous expression of KCNQ1 mRNA. In situ hybridization with an antisense probe to native Xenopus KCNQ1 was performed on embryos at various stages. (DâF) Embryos were embedded in JB4 medium and sectioned at 30 m after hybridization in whole mount. During neurulation, anterior neural plate cells exhibited a strong signal, and expression also was detected in the neural folds (A) and in the mandibular, hyoid, and branchial neural crest streams (B). At tailbud stage, embryos exhibited strong expression in the tail, branchial arches, face, and dorsal neural tube (C); stain in tailbud (D), neural tube (E), and underlying cells around the cement gland (F) was confirmed in section. The extending tail maintained a focus of expression in under the spinal cord (G). Red arrows indicate positive signal. cg indicates cement gland.
Image published in: Morokuma J et al. (2008)
Copyright © 2008. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| kcnq1.L | X. laevis | Sometime during NF stage 11 to NF stage 28 | neural tube tail bud chordoneural hinge posterior wall of neurenteric canal pharyngeal arch mandibular arch branchial arch posterior branchial crest anterior branchial crest cement gland trunk neural crest | |
| kcnq1.L | X. laevis | Throughout NF stage 18 | cranial neural crest neural plate pre-chordal neural plate chordal neural plate neural crest neural plate border chordal neural plate border | |
| kcnq1.L | X. laevis | Throughout NF stage 22 | cranial neural crest mandibular crest branchial crest adenohypophyseal placode neural crest trunk neural crest |
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