Fig. S2. nek2 is expressed in many tissues involved in LR patterning. (A) nek2 is expressed ubiquitously in early stage embryos, but at higher levels in the tissues with more rapidly dividing cells (the animal pole). nek2 is expressed in the LRO (st. 16-17), the mediolateral midline (st. 21 & st. 27) and the lateral plate mesoderm (st.21). (B) Neither knockdown nor overexpression of Nek2 affect mesoderm specification during gastrulation, suggesting that the LRO cilia defect does not arise from an improper specification of superficial mesoderm.
Image published in: Endicott SJ et al. (2015)
Copyright © 2015. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nek2 | nek2a | X. tropicalis | Throughout NF stage 10.5 | whole organism |
| nek2 | nek2a | X. tropicalis | Throughout NF stage 17 | gastrocoel roof plate neural plate neural plate border |
| nek2 | nek2a | X. tropicalis | Throughout NF stage 21 | lateral plate mesoderm head optic vesicle otic placode |
| nek2 | nek2a | X. tropicalis | Throughout NF stage 27 | mesoderm lateral plate mesoderm pronephric mesenchyme tail bud pharyngeal arch head brain otic vesicle spinal cord |
| nek2 | nek2a | X. tropicalis | Throughout NF stage 3 (4-cell) | |
| nek2 | nek2a | X. tropicalis | Sometime during NF stage 8 to NF stage 9 | animal pole |
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