Figure S2: WDR5 regulates foxj1 expression in MCCs. Related to Figure 1. In situ hybridization of (A) MCC markers: dnah9, foxj1, MCIDAS, rfx2 and, (B) non-MCC markers: xeel and atpv1a in uninjected controls and wdr5 morphants. (C) Percentage of embryos with present or reduced cilia driven epidermal flow in response to wdr5 MO and wdr5 MO + Xenopus foxj1 mRNA. (D) Percentage of embryos with normal or reducedexpression of MCC and non-MCC markers. n = number of embryos.â â â indicate statistical significance at P < 0.0005
Image published in: Kulkarni SS et al. (2018)
Copyright © 2018. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| mcidas | idas, mci, mcin, Multicilin | X. tropicalis | Sometime during NF stage 27 to NF stage 29 and 30 | multiciliated epidermal cell eye pharyngeal region |
| dnah9 | dnah9-A, Left-Right Dynein, LRD, L-R Dynein | X. tropicalis | Sometime during NF stage 27 to NF stage 29 and 30 | multiciliated epidermal cell pronephric nephrostome spinal cord |
| itln1 | hl-1, intl, itln, lfr, omentin, xeel | X. tropicalis | Sometime during NF stage 27 to NF stage 29 and 30 | epidermis mucus secreting cell |
| rfx2 | X. tropicalis | Sometime during NF stage 27 to NF stage 29 and 30 | multiciliated epidermal cell pronephric kidney pharyngeal region eye brain spinal cord | |
| foxj1 | foxj1.1, foxj1-a, foxj1-b, hfh-4, hfh4, xfoxj1 | X. tropicalis | Sometime during NF stage 27 to NF stage 29 and 30 | multiciliated epidermal cell pronephric kidney spinal cord proctodeum |
| atp6v1a | atp6a1, atp6v1a1, atpv1a, ho68, v1a, va68, vma1, vpp2 | X. tropicalis | Sometime during NF stage 27 to NF stage 29 and 30 | epidermis ionocyte |
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