Figure 1. Temporal expression of lung and thyroid markers. Whole mount in situ hybridization was used to compare the temporal expression of key early genes in the development of the thyroid and lung. Expression of nkx2.1 is first detectable in the thyroid (red arrows) at stage 30 and is subsequently expressed in the lung (green arrows) at stage 34. Expression of pax2 begins at stage 32 in the thyroid. Expression of the differentiation markers sftpb and sftpc is first detectable at stage 38.
Image published in: Wang JH et al. (2011)
Copyright ©2011 Wang et al; licensee BioMed Central Ltd. Creative Commons Attribution license
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| pax2.L | LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 | X. laevis | Throughout NF stage 29 and 30 | brain midbrain-hindbrain boundary hindbrain neural tube posterior neural tube forebrain telencephalon olfactory bulb pronephric mesenchyme pharyngeal arch neuroectoderm |
| nkx2-1.L | nkx2.1, titf1, ttf1, Xnkx-2.1, xnkx2-1 | X. laevis | Throughout NF stage 29 and 30 to NF stage 32 | thyroid forebrain telencephalon olfactory bulb otic vesicle head region neuroectoderm |
| pax2.L | LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 | X. laevis | Throughout NF stage 32 | brain hindbrain midbrain-hindbrain boundary neural tube posterior neural tube pronephric kidney pronephric duct pronephric nephron neuroectoderm |
| pax2.L | LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 | X. laevis | Throughout NF stage 32 | thyroid brain hindbrain midbrain-hindbrain boundary neural tube posterior neural tube forebrain telencephalon olfactory bulb pronephric kidney pronephric nephron pronephric duct early distal tubule otic vesicle head region |
| nkx2-1.L | nkx2.1, titf1, ttf1, Xnkx-2.1, xnkx2-1 | X. laevis | Sometime during NF stage 33 and 34 to NF stage 40 | lung thyroid endoderm olfactory bulb forebrain telencephalon head region otic vesicle |
| pax2.L | LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 | X. laevis | Throughout NF stage 33 and 34 to NF stage 40 | thyroid endoderm brain midbrain-hindbrain boundary hindbrain neural tube posterior neural tube pronephric kidney pronephric nephron pronephric duct early distal tubule forebrain telencephalon hypothalamus |
| sftpb.L | SP-B, xSP-B | X. laevis | Throughout NF stage 37 and 38 to NF stage 40 | lung endoderm lung primordium |
| sftpc.S | SP-C, SPC, surfc, xSP-C | X. laevis | Throughout NF stage 37 and 38 to NF stage 40 | lung endoderm |
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