Fig. 1. Expression of x-Dll3, x-Nkx2.1, and x-Lhx7 in embryonic Xenopus forebrain. The x-Nkx2.1 protein and GABA neurotransmitter are visualized by immunofluorescence (IF), and the x-Lhx7 and x-Dll3 transcripts are detected by in situ hybridization (ISH, red) revealed by Fast Red and observed in fluorescence (x-Lhx7) or in bright field microscopy (x-Dll3). Panels AâC show lateral views of in toto dissected brains stained with the indicated gene marker at stage 35. Anterior is left, dorsal is up, and the shape of the brain is outlined by a dotted line for fluorescence pictures. (D) Optical and confocal sections through the basal telencephalon of stage 35 embryos labeled for x-Dll3 mRNA or double-labeled for x-Nkx2.1 protein and x-Lhx7 mRNA. Dotted lines delineate subdivisions and neuroepithelial layers. Hyp, hypothalamus; mge, lge, medial and lateral ganglionic eminence; pa, pallium; spa, subpallium; vz/svz/mz, ventricular, subventricular, and marginal zone.
Image published in: Bachy I and Rétaux S (2006)
Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| nkx2-1.L | nkx2.1, titf1, ttf1, Xnkx-2.1, xnkx2-1 | X. laevis | Throughout NF stage 35 and 36 | medial ganglionic eminence hypothalamus diencephalon |
| lhx8.L | lhx7, x-Lhx7 | X. laevis | Throughout NF stage 35 and 36 | medial ganglionic eminence diencephalon subpallium zona limitans intrathalamica forebrain brain |
| dlx5.L | dll3, X-dll3 | X. laevis | Throughout NF stage 35 and 36 | diencephalon subpallium prethalamus lateral ganglionic eminence medial ganglionic eminence zona limitans intrathalamica |
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