Fig. S5. Expression analysis of Insulin/Insulin-like growth factor (Igf) signaling. Whole-mount in situ hybridizations and paraplast sections thereof comparing igf1 (AâBâ²â²), igf3 (CâDâ²â²), insulin receptor (insr) (EâFâ²â²), insulin receptor substrate 1 (GâHâ²â²), igf2 (I), insulin (ins) (K), igf receptor (igfr) (M), and insulin-related receptor (insrr) (N) at stages 34 (A, C, E, G, I, and K) and 38 (BâBâ²â², DâDâ²â², FâFâ²â², HâHâ²â², M, and N). (J and L) In situ hybridizations on paraplast sections of stage 42 Xenopus embryos for igf2 and insulin. Insets show sense control.
Image published in: Romaker D et al. (2014)
Copyright © 2014. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| igf3.L | igf2, igf-3, LOC108697782 | X. laevis | Throughout NF stage 33 and 34 | intermediate mesoderm pharyngeal region head tail lateral plate mesoderm |
| insr.L | cd220, hhf5, insulin receptor, Xe-InsR, XTK1, XTK1a, XTK1b | X. laevis | Throughout NF stage 33 and 34 | pronephric kidney proximal tubule head otic vesicle spinal cord pronephric duct |
| irs1.S | irs-1, LOC108718134 | X. laevis | Throughout NF stage 33 and 34 | intermediate mesoderm pharyngeal region otic vesicle head |
| igf2.L | igf-2, igf2-a, igf2-b, IGF-II, insigf, pp9974 | X. laevis | Throughout NF stage 33 and 34 | pronephric kidney proximal tubule liver primordium |
| ins.L | ins1, ins-a, ins-b, insulin, insulin I, preproinsulin, xins | X. laevis | Throughout NF stage 33 and 34 | pronephric kidney proximal tubule spinal cord |
| igf1.S | igf-1, IGF-I, LOC108712492, Somatomedin, somatomedin-C, xigf1 | X. laevis | Throughout NF stage 37 and 38 | liver |
| igf3.L | igf2, igf-3, LOC108697782 | X. laevis | Throughout NF stage 37 and 38 | head intermediate mesoderm ectoderm lateral plate mesoderm |
| insr.L | cd220, hhf5, insulin receptor, Xe-InsR, XTK1, XTK1a, XTK1b | X. laevis | Throughout NF stage 37 and 38 | pronephric kidney head proximal tubule pronephric duct pharyngeal region spinal cord |
| irs1.S | irs-1, LOC108718134 | X. laevis | Throughout NF stage 37 and 38 | pronephric kidney head proximal tubule spinal cord ectoderm lateral plate mesoderm |
| igf1r.L | igf-1r, xIGF-1R, xigf1r, xIGFR, XTK2 | X. laevis | Throughout NF stage 37 and 38 | pronephric kidney pronephric duct intermediate mesoderm tail head lateral plate mesoderm pharyngeal region spinal cord |
| insrr.L | insulin-related receptor, irr | X. laevis | Throughout NF stage 37 and 38 | pronephric kidney proximal tubule myeloid cell |
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