Fig. 1. Spatiotemporal expression of podocyte genes. (A-Aâ²) Schematics depicting the glomus (black) in whole Xenopus embryos (A) and in transverse section at low (Aâ²) and high (Aâ²) magnification at stage 35. (B-Jâ²) In situ hybridization of podocyte transcription factors wt1 (B-Bâ²), foxc2 (C-Câ²), tcf21 (D-Dâ²), mafb (E-Eâ²) and lmx1b (F-Fâ²) and of markers of podocyte differentiation kirrel (G-Gâ²), nphs1 (H-Hâ²), ptpru (I-Iâ²) and nphs2 (J-Jâ²) at stage 35 in whole-mounts (B-J) and transverse sections (Bâ²-Jâ²). (K) Temporal profile of podocyte gene expression in the glomus. en, endoderm; g, pronephric glomus; lpm, lateral plate mesoderm; no, notochord; nt, neural tube; so, somites; t, pronephric tubules.
Image published in: White JT et al. (2010)
Copyright © 2010. Image reproduced with permission of the Publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| wt1.S | wt-1, wt1-a, wt1-b, Xwt-1, xwt1 | X. laevis | Throughout NF stage 35 and 36 | glomus intermediate mesoderm heart podocyte pronephric kidney |
| foxc2.S | fd-4, fkh7, foxc2-a, foxc2-b, MFH-1, Mfh1, XFD-4 | X. laevis | Throughout NF stage 35 and 36 | eye glomus branchial arch hypaxial muscle tail bud mesenchyme pronephric kidney podocyte |
| tcf21.L | capsulin, epicardin, pod 1, pod1 | X. laevis | Throughout NF stage 35 and 36 | glomus lateral plate mesoderm branchial arch podocyte pronephric kidney |
| mafb.S | kreisler, valentino, xmafb | X. laevis | Throughout NF stage 35 and 36 | lateral plate mesoderm somite glomus early proximal tubule late proximal tubule hindbrain podocyte pronephric kidney eye lens |
| lmx1b.S | lmx1.2, lmx1b.1, nps1, Xlmx1b | X. laevis | Throughout NF stage 35 and 36 | eye glomus otic placode ectoderm neural tube podocyte pronephric kidney |
| kirrel1.L | kirrel, LOC108699399, LOC108700606, neph1, nephrin-like, nphs1l | X. laevis | Throughout NF stage 35 and 36 | brain eye heart glomus branchial arch tail bud exocrine pancreas |
| nphs1.S | nephrin | X. laevis | Throughout NF stage 35 and 36 | glomus podocyte pronephric kidney |
| ptpru.L | fmi, glepp1, LOC108708221, LOC108709564, pcp-2, ptp, ptp-j, ptp-pi, ptppsi, ptpro, ptpu2 | X. laevis | Throughout NF stage 35 and 36 | glomus eye brain neural tube podocyte pronephric kidney forebrain |
| nphs2.L | nphs2l, podocin | X. laevis | Throughout NF stage 35 and 36 | glomus neural tube podocyte pronephric kidney otic placode |
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